It doesn't take long to get used to it, a day or two at most. Just do your daily Araxxor then spend the rest of the day crafting with it off.
Unslain Bosses - Clan
A lot of pro players use default settings or try to keep them as close to default as possible because they use a lot of different computers in tournaments and stuff.
I read an interview with Faker who plays LoL and he said he used to play with an extremely high DPI but then he started playing in tournaments and found he couldn't get the same settings which made it weird for him to play.
He since dropped it to 3.2k which is a more standard speed and says it makes it easier to adapt to other computers when playing on stage etc.
I found myself to misclick a lot less with lower DPI + pointer precision off, but RS isn't really a game where being precise is a complete necessity... So I'd go with personal preference.
I changed it out of pure boredom before, just wanted to try something new. /shrug
Unslain Bosses - Clan