Cleopatra was first married to her older brother, Ptomely XIII. When he died, she married her younger brother, Ptomely XIV. She did not have children with them.
But she had a son with Caeasar, Caeasarion (who died at 17), and twins with Mark Antony (Cleopatra, daughter, and Alexander son) and another son, Ptolemy.
She died due to suicide at the age of 39, shortly after Mark Antony commited suicide at 53.