One of the major quest storylines last year was called "Sliske's Countdown", which was the climax of the tournament for the Stone of Jas. This consisted of Nomad's Elegy, Kindred Spirits, and Children of Mah, all of which led to the final quest: Sliske's Endgame. The other prerequisites for Sliske's Endgame are One of a Kind and Hero's Welcome, and while the quests are separate from Nomad's Elegy, Kindred Spirits, and Children of Mah, I would recommend playing One of a Kind before Hero's Welcome.
You can play Kindred Spirits on its own now, as Nomad's Elegy and Children of Mah are two of the bigger prerequisites. Both of them require Dishonour Among Thieves, where Zamorak gathers a team to stage a heist to steal the Stone of Jas.
Dishonour Among Thieves features the return of Nomad, with Nomad's Elegy picking up where that quests leaves off. However, you also need to do Heart of Stone, which deals with what Zaros warns of in Fate of the Gods, which is that the Elder Gods may soon wake, and also The Mighty Fall, which deals with the aftermath of Armadyl killing Bandos, as the Bandosians decide what to do now that their god is dead.
Children of Mah requires Koschei's Troubles, referring to Koschei the Deathless from The Fremennik Trials, so you just need to talk to him to get a miniquest. Once you finish that, you can also ask him to do what is largely an excuse to train Divination, although that part is totally optional. If your goal would be Children of Mah, then you also need to do The Light Within, which in turn requires Plague's End. Plague's End revolves around the elves of Clan Iorwerth reaching the final stages of their plan to summon the Dark Lord.
The "main" storyline builds on
all
of these quests, so consider Sliske's Endgame the "central" quest you need to get to. However, there are other quests that have nothing to do with that.
05-Mar-2017 15:42:12